Middlebrook Pharmaceuticals discovered in 2000 that bacteria exposed to antibiotics in front-loaded, sequential bursts, or pulses, are killed more efficiently than those exposed to standard antibiotic treatment regimens. The company went on to develop novel anti-infective pulsatile drug products that take advantage of this discovery.

Middlebrook is applying their technology to drugs that may have lost their effectiveness in previous applications. The advantages of pulse therapy are: once-a-day formulation, lower dosages, shorter duration of therapy, reduced side effects, reduced incidence of resistance, combination products with superior efficacy over either product alone, and improved pediatric and geriatric dosages.

The $100M investment in Middlebrook should be exciting for investors. However, some Middlebrook investors were hoping for an outright buyout at $6 to $8 dollars a share by a larger pharmaceutical. This investment shows that the company is viable, and that a serious investment company such as Equity Group Investments, LLC would not have moved

Last Mile Logistics Group (LMLG.OB) is a third-party logistics provider for government agencies, medical providers, professional firms, retailers, telecommunication firms, associations, manufacturers, and other logistic providers. The company services the “last mile” transportation needs of clients in varying industries and offers cost savings by reducing their clients’ carbon footprints.

Last Mile started doing business by focusing on business-to-business (B2B) deliveries that included envelopes and small packages. The company has effectively made the transition from their B2B deliveries to a business-to-consumer (B2C) focus. Last Mile’s B2C focus has grown their third party logistics (3PL) services to deliveries of televisions, appliances, furniture, bedding, and varying high-value merchandise. The company offers deliveries to homes, assembling of products, and communicating scheduled deliveries.

Last Mile intends to acquire other providers of logistics services. The company believes the 3PL market is highly fragmented and sees growth and capital opportunities in future acquisitions.