Middlebrook Pharmaceuticals discovered in 2000 that bacteria exposed to antibiotics in front-loaded, sequential bursts, or pulses, are killed more efficiently than those exposed to standard antibiotic treatment regimens. The company went on to develop novel anti-infective pulsatile drug products that take advantage of this discovery.

Middlebrook is applying their technology to drugs that may have lost their effectiveness in previous applications. The advantages of pulse therapy are: once-a-day formulation, lower dosages, shorter duration of therapy, reduced side effects, reduced incidence of resistance, combination products with superior efficacy over either product alone, and improved pediatric and geriatric dosages.

The $100M investment in Middlebrook should be exciting for investors. However, some Middlebrook investors were hoping for an outright buyout at $6 to $8 dollars a share by a larger pharmaceutical. This investment shows that the company is viable, and that a serious investment company such as Equity Group Investments, LLC would not have moved

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Current top-5 most active stocks on the London Stock Exchange for 10:50am GMT:BTG PLC (BGC): +17.25 +14.02% 140.25p Vol 1.23M Sideways consolidation in play since late-April is no more. Stock follows through on heavy volume. RPC Group PLC (RPC): +18.25 +9.86% 203.25p Vol: 189,644 Has been caught in a trading range with a 200.00p lid since April. Brief forays to 220.00p before failed to ignite this - will this time be different? Synergy Health (SYR): +52.00 +7.27% 767.00p Vol: 230,828 Big jump as it works on a challenge of 6-month highs around 800.00p; subsequent resistance can be found at 850.00p and 900.00p, but beyond is plenty of clean air. ROC Oil (ROC): +7.50 +7.25% 111.00p Vol: 23,206 Much work to do to break its recent deline from 130.00p. Layers of additional resitance up to 180.00pPetra Diamonds (PDL): +7.00 ...

The Qs are stabilizing better than the SPY, but the declining 5DMA offered resistance on the first rally attempt. Adam from the Daily Options Report came up with a list of QUESTIONS after reading my book.

Nasdaq is up, but backing away from the 48.50 level identified as potential resistance in last nights video. The SPY is down slightly, but remains under 140 and the 5 DMA is now declining.

of the SPY show a lower high and some resistance near 49.25 in the Qs. Yesterday's rally has lost momentum and it may signal a need for more sideways action to digest the gains of the last month.

In yesterday’s video I mentioned that we wanted to see a pullback to prior resistance near 124 and then to buy the stock once the buyers re-established short term control of the stock. We got the pullback, but it kept pulling back, so the stock should not have been purchased. We never know if a prior level of resistance will act as support, they are only POTENTIAL levels where we want to study price action further for evidence which backs our theory. Right now, I would avoid RIMM until it can show signs that the buyers have take back control of the short term trends.

 

The Fed reversal started late in the day, although futures suggest a higher open. The Dow flashed a (bearish) gravestone doji on higher volume, with the 200-day MA lurking overhead to act as resistance. A push back to the 50-day MA looks the most favored response to relieve overbought conditions, but any close higher today would make a strong case for a 200-day MA breakout. Why? The current set-up looks picture perfect from a bear’s perspective, so if it didn’t play to expectation you would have to be worried (from the bear side).

The Nasdaq 100 has inched its way to the 200-day MA. The gap created at 1,850 looks a logical downside target, but it wouldn’t take much buying to push …

As I stated in yesterday’s video, the markets have been trying to work through resistance (140- SPY) and they seem tired. The Nasdaq 100 has made a lower high and making a lower low below 46.50 would break the put that market back below the recent uptrend line and below the 5DMA. If the Qs cannot hold above 46.50 and SPY breaks below 138, I would interpret that as a reason to be more defensive.