Early this morning, Novartis AG (
NVS) announced that data from a two year late-stage study showed that its oral drug FTY720 (fingolimod) was significantly superior to placebo in reducing relapses and disability progression in patients with relapsing-remitting multiple sclerosis (MS).
The double-blind placebo-controlled study, called FREEDOMS (FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis), involved 1,272 patients in 22 countries and assessed the efficacy, safety and tolerability of FTY720. The study revealed that FTY720, which was well tolerated in the study, reduced the relapse rate by 54% for the 0.5 mg dose and 60% for the 1.25 mg dose compared to placebo.
Furthermore, the candidate reduced disability progression by 30% for patients on 0.5 mg and 32% for those on 1.25 mg compared to placebo over the entire duration of the study, thus meeting the primary and secondary endpoints for both the doses, with ...
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