Middlebrook Pharmaceuticals discovered in 2000 that bacteria exposed to antibiotics in front-loaded, sequential bursts, or pulses, are killed more efficiently than those exposed to standard antibiotic treatment regimens. The company went on to develop novel anti-infective pulsatile drug products that take advantage of this discovery.

Middlebrook is applying their technology to drugs that may have lost their effectiveness in previous applications. The advantages of pulse therapy are: once-a-day formulation, lower dosages, shorter duration of therapy, reduced side effects, reduced incidence of resistance, combination products with superior efficacy over either product alone, and improved pediatric and geriatric dosages.

The $100M investment in Middlebrook should be exciting for investors. However, some Middlebrook investors were hoping for an outright buyout at $6 to $8 dollars a share by a larger pharmaceutical. This investment shows that the company is viable, and that a serious investment company such as Equity Group Investments, LLC would not have moved

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Since exchange-traded funds (ETFs) were first introduced in 1993, interest in them has grown steadily. In one year alone, ETF assets increased by a staggering 49% to reach $588.2 billion.

Although ETFs resemble index mutual funds, they actually have a lot in common with individual shares of stock. ETFs can be purchased on margin, sold short, and traded any time the markets are open. If you are seeking an investment that can offer the benefits of both mutual funds and stocks, an ETF may be an option to consider.

An ETF is a passively managed portfolio of securities that is initially sold by an investment company and thereafter traded in individual shares on a stock exchange. The underlying securities may all be from a certain sector or country, or they may track a broad market index.

Taking Stock

ETF share prices are more likely to be based on the demand for the shares themselves

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Cavico Corp. (CVIC.OB) is a major infrastructure construction and investment company also focusing on natural resources. The company is a leading hydropower construction company and the largest privately-owned heavy civil construction contractor located in Vietnam. The company is committed to offering social and economic improvements in all communities where it has operations.

Cavico plays a strong role in the infrastructure development of Vietnam’s manufacturing industry. The company specializes in hydroelectric plants, highways, bridges, tunnels, roads, dams, and urban community developments. Cavico also holds a reputation for being a responsible provider of infrastructure by being conscious of environmental issues and applications. The company makes investments not only in hydropower facilities, but also in cement production plants and urban developments in Vietnam.

Cavico operates throughout more than twenty countries and has approximately 3,000 employees. The company is headquartered in Hanoi, Vietnam, but also has additional offices throughout Vietnam

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