The FDA has published a table with the names of products and potential signals of serious risks and/or new safety information identified for these products during 1Q08 in the AERS database. The FDA notes that patients should not stop taking these medications and should consult their prescriber with any questions as the agency will investigate each of the claims further before taking action or issuing more definitive statements on the reported concerns. Some highlights from this table of products that are sold by public-traded pharma and biotech companies are listed below in the following format: active ingredient (brand name) - company(ies) - new safety information reported. Duloxetine (Cymbalta) - Eli Lilly (LLY) - Urinary retention Heparin - Baxter (BAX) & APP Pharma (APPX) - Anaphylactic-type reactions Lapatinib (Tykerb) - GlaxoSmithKline (GSK) – Liver toxicity Lenalidomide (Revlimid) - Celgene (CELG) – ...

Adolor Corporation (Nasdaq: ADLR) is a biopharmaceutical company specializing in the discovery, development and commercialization of novel prescription pain management products. The company announced GlaxoSmithKline (GSK) returned to Adolor the worldwide rights related to Entereg for chronic opioid bowel dysfunction (OBD), as well as rights related to Entereg for irritable bowel syndrome (IBS).

While GSK will retain the rights to Entereg in regards to postoperative ileus (POI), Adolor will work with GSK to coordinate development and commercialization of Entereg for POI in the United States.

OBD is commonly described as constipation, but also includes other gastrointestinal effects such as abdominal cramping, bloating and gastroesophageal reflux. According to Michael R. Dougherty, president and CEO of Adolor, the company intends on addressing the needs for individuals affected by OBD.

“There is a large, unmet need for treatment options for the many patients who suffer with chronic OBD,” Dougherty stated in the

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