Middlebrook Pharmaceuticals discovered in 2000 that bacteria exposed to antibiotics in front-loaded, sequential bursts, or pulses, are killed more efficiently than those exposed to standard antibiotic treatment regimens. The company went on to develop novel anti-infective pulsatile drug products that take advantage of this discovery.

Middlebrook is applying their technology to drugs that may have lost their effectiveness in previous applications. The advantages of pulse therapy are: once-a-day formulation, lower dosages, shorter duration of therapy, reduced side effects, reduced incidence of resistance, combination products with superior efficacy over either product alone, and improved pediatric and geriatric dosages.

The $100M investment in Middlebrook should be exciting for investors. However, some Middlebrook investors were hoping for an outright buyout at $6 to $8 dollars a share by a larger pharmaceutical. This investment shows that the company is viable, and that a serious investment company such as Equity Group Investments, LLC would not have moved

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With the continuation yesterday of Friday’s market weakness, the last of our April 3 calendar-spread bonus trades hit its minimum profit target. Here’s a summary of the three positions: EEM May/June 140 - Reached 20% profit on April 15, less than two weeks into the trade. XLE May/June 77 - Even if entered at the less-than-optimal price of $1.20, this position achieved our 20% minimum profit target on the sell-off in energy that occurred May 1, which was within 4 weeks of entering. IYR May/June 69 - The iShares real-estate ETF proved stronger than we expected, but a week ago the spread was trading near a 20% gain. It would’ve been hard to get an order filled at the target price of $1.50 last week, but today the mid price rose as high as $1.575, ...

Not expecting too much for today, so took a look at what’s going on my feed reader:

CXO Advisory takes a look at AlphaKing:
In summary, testing indicates that the AlphaKing Trading Indicator may have some value for timing the Nasdaq Composite index, but the duration of the live data sample is much too short for reliable inference.
Financial Week looks at blogmining.

Econoblogging as a step towards a job.

Vix and More on High Implied Volatility.

Wall St. Warrior always has a great pre-market warm up. Not expecting much today

Herb Greenberg’s five lesson’s learnt. (Via Maoxian via TraderMike)

Why things cost $19.95 (Via Maoxian)

How to monitor websites that don’t have RSS feeds – handy (Via Maoxian)

Bill Rempel’s Seven Quantifiable Ways to Define Trend. The Average Directional Index is …